Arturo Casadevall, Bloomberg distinguished professor and chair of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health. Since biofilm formation helps bacteria resist drugs and to attach to tissues the compound (or a derivative) could be clinically useful.” “They report a plant-derived compound that inhibits biofilm formation. When DIM was combined with the antibiotic tobramycin, the biofilm growth of P. In this experiment, 50µM DIM inhibited biofilm growth by 65% and 70%, respectively. aeruginosa, both of which are multi-drug resistant and therefore clinically important. would be nice to see if these data are similar in other important and gram-positive bacteria such as Staphylococcus aureus.”įollowing their initial findings, the researchers then focused on A. “Biofilm formation was markedly inhibited by DIM in two of the pathogenic bacteria studied. Taking larger doses of diindolylmethane is possibly unsafe. Satola told Medical News Today she would like to see more investigations: The most common side effects include headache, nausea, vomiting, gas, and diarrhea. In all four bacteria, DIM reduced the biofilm formation by up to 80%.ĭr. Gram-negative bacteria have a high resistance to antibiotics. Supplementing the diet with DIM and eating cruciferous vegetables increases the specific aerobic. The researchers investigated four gram-negative pathogenic bacteria - Pseudomonas aeruginosa PAO1, Acinetobacter baumannii, Serratia marcescens, and Providencia stuartii strains. DIM stimulates more efficient metabolism for estrogen. Sarah Satola, associate professor of medicine and infectious Diseases, director at Emory University School of Medicine’s Investigational Clinical Microbiology Core After menopause, women’s bodies make less estrogen. According to American Thyroid Association, women are four to five times more prone to developing thyroid disorders than men, with pregnancy and early menopause increasing the risk (), suggesting the significance of hormonal factors such as estrogen in the etiology and pathogenesis of TPD. The longer a bacteria is exposed to the antibiotic, the greater the risk of the bacteria becoming heteroresistant or even resistant.” DIM may also reduce the effectiveness of oral birth control medications. The most concerning potential side effect is that a person will have an allergic reaction to the Dim supplement. Treating an infection that has formed a biofilm, and the source of the biofilm may require a longer course of an antibiotic(s). “The ability to safely disrupt a bacterial biofilm has the potential to reduce antibiotic resistance. In this study, researchers investigated the effects of DIM on biofilms formed by pathogenic bacteria.
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